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Serotype 35B Streptococcus pneumoniae, Japan, 2002-2012

Kei Kasahara1, Yuko Komatsu1, Akira Koizumi2

  • 1Center for Infectious Diseases, Nara Medical University, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|January 28, 2014
PubMed

Insights

Pneumococcal serotype 35B was found in 3.0% of isolates in Japan between 2002-2012. Most were ST558 or ST2755, highlighting the need for ongoing serotype and clonal monitoring.

Area of Science:

  • Microbiology
  • Epidemiology
  • Immunology

Background:

  • Streptococcus pneumoniae causes invasive pneumococcal disease.
  • Serotype 35B is a rare but significant pneumococcal serotype.
  • Vaccine recommendations and epidemiology evolve over time.

Purpose of the Study:

  • To characterize pneumococcal serotype 35B isolates in Japan.
  • To determine the clonal types associated with serotype 35B.
  • To inform ongoing surveillance strategies for pneumococcal disease.

Main Methods:

  • Retrospective analysis of pneumococcal isolates collected from 2002 to 2012.
  • Serotyping of isolates to identify serotype 35B.
  • Multilocus sequence typing (MLST) to determine sequence types (STs).

Main Results:

  • 19 out of 641 (3.0%) pneumococcal isolates were identified as serotype 35B.
  • Twelve serotype 35B isolates belonged to ST558, a variant of Utah35B-24-ST377.
  • Seven serotype 35B isolates were identified as ST2755.

Conclusions:

  • Serotype 35B pneumococci were detected in Japan during the study period.
  • Specific sequence types, ST558 and ST2755, were associated with serotype 35B.
  • Continuous monitoring of pneumococcal serotypes and their clonal associations is crucial, particularly in Japan following the introduction of PCV7.
Keywords:
Pneumococcal vaccineSerotype replacementStreptococcus pneumoniae

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