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Serotype 35B Streptococcus pneumoniae, Japan, 2002-2012
Kei Kasahara1, Yuko Komatsu1, Akira Koizumi2
1Center for Infectious Diseases, Nara Medical University, Japan.
Summary
Pneumococcal serotype 35B was found in 3.0% of isolates in Japan between 2002-2012. Most were ST558 or ST2755, highlighting the need for ongoing serotype and clonal monitoring.
Area of Science:
- Microbiology
- Epidemiology
- Immunology
Background:
- Streptococcus pneumoniae causes invasive pneumococcal disease.
- Serotype 35B is a rare but significant pneumococcal serotype.
- Vaccine recommendations and epidemiology evolve over time.
Purpose of the Study:
- To characterize pneumococcal serotype 35B isolates in Japan.
- To determine the clonal types associated with serotype 35B.
- To inform ongoing surveillance strategies for pneumococcal disease.
Main Methods:
- Retrospective analysis of pneumococcal isolates collected from 2002 to 2012.
- Serotyping of isolates to identify serotype 35B.
- Multilocus sequence typing (MLST) to determine sequence types (STs).
Main Results:
- 19 out of 641 (3.0%) pneumococcal isolates were identified as serotype 35B.
- Twelve serotype 35B isolates belonged to ST558, a variant of Utah35B-24-ST377.
- Seven serotype 35B isolates were identified as ST2755.
Conclusions:
- Serotype 35B pneumococci were detected in Japan during the study period.
- Specific sequence types, ST558 and ST2755, were associated with serotype 35B.
- Continuous monitoring of pneumococcal serotypes and their clonal associations is crucial, particularly in Japan following the introduction of PCV7.
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