Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Complement System

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A pH-Responsive Antimicrobial Peptide Coating with Efficient Antibacterial Activity and Preserved Oral Microbiota Homeostasis during Clear Aligner Treatment.

ACS applied materials & interfaces·2026

Same author

The mouse-lethal H5N1 influenza virus carrying the PB2-384L/443R/460M characteristics acquired in avian hosts can effectively utilize human ANP32A/B proteins.

Emerging microbes & infections·2026

Same author

Preparation, Interaction Mechanism and Application of Functional Ionic Liquid-Mediated Protein Imprinting Technique.

Polymers·2026

Same author

Harnessing Multi-Anchoring Effects for the Fabrication and Specific Recognition of Surface-Oriented Imprinted Nanospheres for Cytochrome C.

Polymers·2026

Same author

A nanobody-based proteolysis-targeting chimera offers broad-spectrum protection against diverse influenza virus infections.

Signal transduction and targeted therapy·2026

Same author

The current situation and perspectives of bacteriophage-derived endolysins for controlling foodborne pathogens and their biofilms in food industry.

International journal of biological macromolecules·2026

Same journal

Characterization of interleukin-20 from black carp and its role in the antiviral innate immunity.

Developmental and comparative immunology·2026

Same journal

The spatiotemporal immune response patterns of Gryllus bimaculatus to infection by the bioinsecticide Metarhizium anisopliae.

Developmental and comparative immunology·2026

Same journal

Characterization and determination of the immunomodulatory activity of intestinal microbiota microorganisms isolated from free-range Cornu aspersum snails in olive groves before and after aestivation.

Developmental and comparative immunology·2026

Same journal

Comprehensive analysis of pathogenic mechanisms of Enterobacter cancerogenus ECL9 in silkworms.

Developmental and comparative immunology·2026

Same journal

Isolate-Dependent Pathogenicity and Host-Pathogen Interactions of Toxigenic Penicillium roqueforti in the Galleria mellonella Model.

Developmental and comparative immunology·2026

Same journal

PPARγ mediates selenomethionine-induced suppression of NF-κB signaling in bovine endometrial epithelial cells.

Developmental and comparative immunology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

Complement system in zebrafish.

Shicui Zhang¹, Pengfei Cui¹

¹Laboratory for Evolution & Development, Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, China.

Developmental and Comparative Immunology

|January 28, 2014

Summary

This summary is machine-generated.

Zebrafish possess all known mammalian complement system components. Research highlights unique features like diverse gene forms and widespread expression, crucial for understanding innate immunity in this model organism.

Keywords:

Complement Expression Function Regulation Zebrafish

More Related Videos

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Published on: September 12, 2013

Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Published on: January 24, 2025

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Author Spotlight: Mapping Cellular Connectivity in the Zebrafish Nervous System During Development and Regeneration

Published on: July 5, 2024

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish

Published on: September 12, 2013

Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Published on: January 24, 2025

Area of Science:

Immunology
Comparative genomics
Zebrafish models

Background:

The complement system is vital for innate immunity.
Zebrafish are increasingly used to study human diseases and immunology.
Knowledge of the zebrafish complement system has rapidly advanced.

Purpose of the Study:

To review current research on the zebrafish complement system.
To highlight the conservation and unique features of zebrafish complement components.
To identify future research directions for understanding complement function in zebrafish.

Main Methods:

Global searching of genome databases for complement components.
Analysis of published data on zebrafish complement system.
Comparative analysis with mammalian complement systems.

Main Results:

All known mammalian complement component orthologues exist in zebrafish.
Zebrafish complement components show prominent extrahepatic expression.
Distinctive features include isotypic diversity of complement components.

Conclusions:

Zebrafish complement system is highly conserved but has unique characteristics.
Further research is needed to identify specific genes and elucidate functions.
Understanding zebrafish complement is key for its use as an immunology model.