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Inflammation and the developing brain: consequences for hippocampal neurogenesis and behavior
Holly F Green1, Yvonne M Nolan1
1Department of Anatomy and Neuroscience, University College Cork, Ireland.
Neuroscience and Biobehavioral Reviews
|January 28, 2014
Summary
Early-life inflammation negatively impacts developing brain
Area of Science:
- Neuroscience
- Developmental Biology
- Immunology
Background:
- Inflammation's negative effects on adult brain neurogenesis are known.
- Research on inflammation's impact on the developing brain is rapidly expanding.
- Pro-inflammatory mediators disrupt hippocampal neurogenesis and neuronal structure during development.
Purpose of the Study:
- To review current literature on inflammation-induced changes in early-life hippocampal neurogenesis.
- To examine consequent long-term behavioral deficits.
- To explore mechanisms linking early inflammation to neurodevelopmental disorders and cognitive dysfunction.
Main Methods:
- Comprehensive literature review.
- Analysis of cellular and molecular mechanisms.
- Examination of neurodevelopmental disorder models.
Main Results:
- Early-life inflammation adversely affects hippocampal neurogenesis and neuronal development.
- These changes are linked to behavioral deficits later in life.
- Specific cellular and molecular pathways are implicated in inflammation-induced neurodevelopmental changes.
Conclusions:
- Early-life inflammation poses a significant risk for neurodevelopmental and cognitive impairments.
- Understanding these mechanisms may inform future therapeutic strategies.
- Further research is needed to fully elucidate the long-term consequences of early-life inflammation on brain development and behavior.
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