Related Experiment Video
Updated: May 3, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells
Myoung Seok Ko1, Hyo Jeong Kim2, Hong Kyung Kim2
1Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea; Department of Medical Science, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Abstract:
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of T(H)17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE.
More Related Videos
04:43Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
07:46Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
Published on: October 25, 2024
Related Concept Videos
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
TGF - β Signaling Pathway
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
GTPases and their Regulation
Large G-proteins,...
GPCRs Regulate Adenylyl Cylase Activity