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Updated: May 3, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
Published on: June 12, 2011
Ultrasound mediated transdermal drug delivery
Aharon Azagury1, Luai Khoury2, Giora Enden2
1Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel.
Abstract:
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.
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