Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The American Journal of Ophthalmology Reckons With "Race" and "Ethnicity".

American journal of ophthalmology·2026

Same author

Leveraging Big Data to Advance Our Understanding of Pigmentary Glaucoma.

Ophthalmology·2026

Same author

Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

American journal of ophthalmology·2026

Same author

REPLY.

Ophthalmology·2026

Same author

Topographic Agreement of Retinal Nerve Fiber and Ganglion Cell Loss Improves Incipient Glaucoma Detection.

Ophthalmology. Glaucoma·2026

Same author

Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern®.

Ophthalmology·2026

Search research articles

Related Experiment Video

Updated: May 3, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Evidence-based management of primary angle closure glaucoma.

Matthew E Emanuel¹, Richard K Parrish, Steven J Gedde

¹Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Current Opinion in Ophthalmology

|January 28, 2014

Summary

Primary angle closure (PAC) management varies. While laser peripheral iridotomy is beneficial for symptomatic cases, cataract extraction shows promise for controlling intraocular pressure (IOP) in PAC and related conditions.

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Related Experiment Videos

Last Updated: May 3, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Area of Science:

Ophthalmology
Glaucoma Research

Background:

Primary angle closure (PAC) is a significant cause of vision loss.
Accurate classification is crucial for effective management.

Purpose of the Study:

To review the classification of primary angle closure (PAC).
To discuss the evidence-based management strategies for each PAC type.

Main Methods:

Literature review of existing studies on PAC classification and treatment.
Analysis of evidence supporting various management options.

Main Results:

Limited evidence supports prophylactic treatment for primary angle closure suspects.
Cataract and clear lens extraction may be more effective for intraocular pressure (IOP) control in PAC, primary angle closure glaucoma, and acute angle closure crisis compared to traditional therapies.

Conclusions:

Treatment for angle closure is guided by signs of chronic angle damage and glaucomatous optic neuropathy.
Serial gonioscopy may be preferred in the absence of such damage.
Medical therapy and laser peripheral iridotomy are beneficial if signs or symptoms are present.
Emerging data suggest cataract extraction may be superior to laser or incisional glaucoma procedures for IOP control.