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Updated: May 3, 2026

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Sandwich-like Microenvironments to Harness Cell/Material Interactions

Published on: August 4, 2015

Engineering biomolecular microenvironments for cell instructive biomaterials.

Catarina A Custódio¹, Rui L Reis, João F Mano

¹3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909, Caldas das Taipas - Guimarães, Portugal; ICVS/3B's, PT Government Associated Laboratory, Braga/Guimarães, Portugal.

Advanced Healthcare Materials

|January 28, 2014

Summary

This summary is machine-generated.

Engineered cell microenvironments guide cell behavior for tissue engineering. This review explores biochemical signals and fabrication methods for creating bioactive biomaterials that mimic the natural cell niche.

Keywords:

biomaterials cell microenvironments functional materials tissue engineering

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Sandwich-like Microenvironments to Harness Cell/Material Interactions

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Published on: August 4, 2015

Fabrication and Use of MicroEnvironment microArrays MEArrays

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Published on: June 2, 2022

Area of Science:

Biomaterials Science
Tissue Engineering
Cell Biology

Background:

Cells respond dynamically to their in vivo microenvironment, or "niche," which includes the extracellular matrix and neighboring cells.
This niche influences cell structure, mechanics, polarity, and function.
Replicating the dynamic in vivo microenvironment is crucial for effective tissue engineering.

Purpose of the Study:

To review biochemical signals used in fabricating bioactive cell microenvironments.
To summarize key technologies and chemical strategies for encoding biological information into engineered biomaterials.

Main Methods:

Focuses on reviewing existing literature on biochemical signals and fabrication techniques.
Highlights micro and nanofabrication approaches for creating tunable microenvironments.
Discusses strategies for incorporating biological information into biomaterials.

Main Results:

Bioactive tunable microenvironments using micro/nanofabrication effectively control intracellular signaling and cell function.
Various biochemical signals have been explored to create these instructive microenvironments.
Engineered biomaterials can be designed to present specific structural, mechanical, and biochemical cues.

Conclusions:

Engineered cell microenvironments are vital for advancing tissue engineering.
The strategic use of biochemical signals and advanced fabrication techniques is key to developing functional biomaterials.
Controlled biomaterial design can precisely guide cellular responses for therapeutic applications.