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Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Heterocycles 33: lipophilicity of a new class of thioethers estimated by reversed-phase thin-layer chromatography and
Alexandra Toma1, Denisa Hapău2, Dorina Casoni3
1Department of Organic Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Victor Babeş 41, Ro-400012 Cluj-Napoca, Romania.
Abstract:
The retention behavior for a series of new polyheterocyclic compounds containing azolic rings (1,3-thiazole, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole) has been investigated using reversed-phase thin-layer chromatography. Different approaches and computational methods were employed to evaluate their lipophilicity indices derived from chromatographic parameters. The obtained experimental results were correlated with various lipophilicity indices estimated via different computer software and internet websites. A strong correlation between experimental and computed results was observed. Furthermore, the lipophilicity parameters obtained by applying principal component analysis divided the investigated compounds into four groups according to their structural similarities.
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