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The effect of trapidil and bevacizumab on tracheal anastomotic wound healing
Esra Ertan1, Perihan Göçer2, Ali Naycı3
1Yedikule Chest Disease Hospital, Istanbul, Turkey.
Background:
Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses.
Objective:
We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection.
Materials And Methods:
We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day.
Results:
The bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047).
Conclusions:
Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.
