Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
Epigenetic Regulation01:46

Epigenetic Regulation

24.1K
24.1K
Gene-Environment Interactions01:20

Gene-Environment Interactions

1.4K
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
1.4K
Cancer Prevention02:59

Cancer Prevention

6.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.5K
Epistasis Analysis01:09

Epistasis Analysis

4.9K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrically Tunable Tunneling and Spectral Response in WSe<sub>2</sub>/h-BN/CdSe/Graphene Heterostructure.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

TBK1-NQO1 negative feedback loop regulates antiviral innate immunity.

Cell communication and signaling : CCS·2026
Same author

High-Gain Ag<sub>2</sub>Te/MoS<sub>2</sub> Hybrid Photodetectors for Short-Wave Infrared Imaging.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Genome-resolved, preclinical safety evaluation of infant-derived Clostridium butyricum S-45-5 as a probiotic candidate.

BMC microbiology·2026
Same author

Small heterodimer partner protects against osteoarthritis by inhibiting IKKβ/NF-κB-mediated matrix-degrading enzymes in chondrocytes.

Nature communications·2026
Same author

Foot-and-mouth disease virus VP4 interferes with host interferon response by targeting the nuclear translocation of interferon regulatory factor 3 (IRF3).

Veterinary research·2026

Related Experiment Video

Updated: May 3, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.0K

Interplay between Epigenetics and Genetics in Cancer.

Jae Duk Choi1, Jong-Soo Lee1

  • 1Department of Life Science, College of Natural Sciences, Ajou University, Suwon 443-749, Korea.

Genomics & Informatics
|January 28, 2014
PubMed
Summary

Genomic instability and epigenomic aberrations drive cancer by altering gene function. These genetic and epigenetic mechanisms intertwine, with heterochromatin protein 1 playing a key role in maintaining genome integrity during tumorigenesis.

Keywords:
epigenomicsgeneticsheterochromatin-specific nonhistone chromosomal protein HP-1neoplasms

More Related Videos

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

7.0K

Related Experiment Videos

Last Updated: May 3, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

10.0K
Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.5K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

7.0K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Genomic instability and epigenomic aberrations are hallmarks of cancer, promoting tumorigenesis and progression.
  • These alterations involve DNA sequence changes (mutations, aneuploidy) and epigenetic modifications (DNA methylation, histone changes).
  • Epigenetic disruption includes widespread hypomethylation and specific hypermethylation of tumor suppressor genes, alongside aberrant histone modifications and miRNA profiles.

Purpose of the Study:

  • To explore the interplay between genetic and epigenetic mechanisms in cancer development.
  • To elucidate how alterations in epigenetic molecules contribute to cancer biology.
  • To discuss the role of heterochromatin protein 1 in mediating the collusion between epigenetics and genetics for genome integrity.

Main Methods:

  • Review of existing literature on genomic instability and epigenomic aberrations in cancer.
  • Analysis of molecular details regarding the modulation of epigenetic events.
  • Discussion of the role of heterochromatin protein 1 in genetic-epigenetic interactions.

Main Results:

  • Genomic instability and epigenomic aberrations lead to dysregulation of tumor suppressor genes and oncogenes.
  • Epigenetic alterations manifest as large-scale DNA hypomethylation, specific tumor suppressor gene hypermethylation, aberrant histone modifications, and altered miRNA expression.
  • Evidence suggests genetic and epigenetic mechanisms are not independent but collaborate during tumorigenesis.

Conclusions:

  • The intricate crosstalk between genetic and epigenetic factors is crucial for cancer initiation and progression.
  • Understanding these intertwined mechanisms, particularly the role of heterochromatin protein 1, is vital for developing targeted cancer therapies.
  • Aberrant epigenetic modifications and their interaction with genetic instability represent a critical area for future cancer research.