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Updated: May 3, 2026
Measuring Neuromuscular Junction Functionality
Published on: August 6, 2017
Myasthenia in acquired neuromyotonia
Jung-Ick Byun1, Hye-Jin Moon2, Yoon-Ho Hong3
1Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Background:
Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness is unusual unless autoimmune myasthenia gravis (MG) is superimposed.
Case Report:
A case of acquired NMT accompanied by exertional weakness without coexistence of seropositive MG is reported herein.
Conclusions:
Clinical and electrophysiological observations suggest that the cholinergic overactivity in NMT can compromise the safety factor sufficiently to cause a defect in neuromuscular junction transmission.
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