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Studies on in vitro interferon induction capacity and interferon sensitivity of simian foamy viruses
A Rhodes-Feuillette1, F Saal, J Lasneret
1Laboratoire de Virologie des Leucémies, CNRS, Centre Hayem, Hôpital Saint Louis, Paris, France.
Archives of Virology
|January 1, 1987
Abstract:
We demonstrate that Simian Foamy viruses (SFV) types 1, 2, 4 and 10 do not induce Interferon (IFN) production in mouse and primate (simian and human) cell lines, but that their cytopathogenic effect is blocked by this viral inhibitor. The mechanisms of action of IFN seems to be different from that of other Retroviridae. No trapping of virions appears in treated cells examined by ectron microscopy. Moreover, neither precursor nor mature virus particles were observed in infected cultures submitted to IFN treatment.