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Allergic Reactions

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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

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Related Experiment Video

Updated: May 3, 2026

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Peripheral erythrocytes decrease upon specific respiratory challenge with grass pollen allergen in sensitized mice

Galateja Jordakieva¹, Julia Wallmann², René Schmutz³

¹Comparative Medicine, Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna & University of Vienna, Vienna, Austria ; Institute of Occupational Medicine, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria.

|January 28, 2014

Summary

This summary is machine-generated.

Acute respiratory allergen exposure significantly impacts red blood cells (erythrocytes) in both mice and humans, suggesting their role in hypersensitivity reactions. This study highlights erythrocyte involvement beyond leukocytes in allergic responses.

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Last Updated: May 3, 2026

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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

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Published on: July 10, 2018

Area of Science:

Immunology
Respiratory Medicine
Allergy Research

Background:

Allergic respiratory diseases significantly impair quality of life due to allergen-specific hyper-responsiveness and non-specific airway hyperreactivity.
Understanding cellular responses to both specific and non-specific airway challenges is crucial for managing these conditions.

Purpose of the Study:

To investigate local and systemic cellular responses following specific and non-specific airway challenges.
To compare responses in sensitized BALB/c mice challenged with grass pollen allergen Phl p 5 and in grass pollen-sensitized allergic rhinitis subjects.

Main Methods:

Sensitized BALB/c mice were challenged with specific allergen (Phl p 5) or non-specific antigen (ovalbumin).
Grass pollen-sensitized human subjects underwent specific airway challenge in the Vienna Challenge Chamber (VCC).
Evaluated physical activity, airway inflammation markers, leukocyte infiltration, cytokine expression, and circulating blood cell dynamics.

Main Results:

Both mouse groups showed reduced physical activity post-challenge. Specific challenge led to goblet cell hyperplasia, increased mucus, leukocyte infiltration, and specific cytokine expression (IL-4, IL-5, IL-13).
A significant drop in erythrocyte counts, hemoglobin, and hematocrit was observed in both challenged mice groups.
Human subjects showed a similar decrease in circulating erythrocytes and hematocrit after allergen challenge, contrasting with leukocyte responses.

Conclusions:

Erythrocytes, in addition to leukocytes, play a significant role in acute hypersensitivity reactions to respiratory allergens.
Rapid erythrocyte recruitment to the lungs may be a compensatory mechanism for hypoxia during allergic responses.