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Solid Plate-based Dietary Restriction in Caenorhabditis elegans
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Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility.

Stephen D Anton1, Christy Karabetian2, Kacey Heekin1

  • 1Department of Aging and Geriatric Research, Institute on Aging, 2004 E. Mowry Road, University of Florida, Gainesville, FL 32610, (352) 273-7514.

Current Translational Geriatrics and Experimental Gerontology Reports
|January 28, 2014
PubMed
Summary

Caloric restriction (CR) shows promise for extending lifespan and healthspan in animals. However, poor long-term adherence in humans hinders its benefits, necessitating strategies to improve CR compliance.

Keywords:
AgingCaloric restrictionadherenceappetitebody weighthealth-spanlife-spanlifestyle

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Public Health

Background:

  • Increasing life expectancy in the US highlights the need for interventions to maintain physical and cognitive independence in older adults.
  • Age-associated diseases like cancer and diabetes pose significant health challenges, emphasizing the search for effective preventative strategies.
  • Caloric restriction (CR) is the sole intervention consistently shown to increase lifespan and delay age-related diseases across species.

Purpose of the Study:

  • To address the challenge of poor long-term adherence to caloric restriction (CR) in humans.
  • To identify potential methods that can support individuals in maintaining CR over extended periods.
  • To explore interventions that promote healthspan and prevent disability in aging populations.

Main Methods:

  • This study reviews existing literature on caloric restriction (CR) and human adherence.
  • It examines the behavioral, physiological, psychological, and environmental factors influencing CR compliance.
  • The research synthesizes findings to identify barriers and potential facilitators for long-term CR.

Main Results:

  • Long-term adherence to CR regimens in humans is notoriously poor.
  • Adherence is influenced by a complex interplay of behavioral, physiological, psychological, and environmental factors.
  • Current methods for maintaining CR are insufficient for widespread, long-term application.

Conclusions:

  • Improving long-term adherence to CR is critical for realizing its potential health benefits in humans.
  • Further research is needed to develop effective strategies supporting sustained CR.
  • Addressing adherence challenges is a key priority for leveraging CR in public health and clinical practice.