Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

12.5K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
12.5K
Protein Complex Assembly02:41

Protein Complex Assembly

1.6K
1.6K
Protein Organization01:13

Protein Organization

123.3K
Overview
123.3K
Protein Organization01:24

Protein Organization

7.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
7.2K
Protein Organization01:24

Protein Organization

9.0K
9.0K
Protein and Protein Structure02:15

Protein and Protein Structure

71.5K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
71.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An update on the impact of postnatal systemic corticosteroids on mortality and cerebral palsy in preterm infants: effect modification by risk of bronchopulmonary dysplasia.

The Journal of pediatrics·2014
Same author

Changes in circulating red cell volume during the first 6 weeks of life in very-low-birth-weight infants.

Pediatric research·2013
Same author

A generalised model for individualising a treatment recommendation based on group-level evidence from randomised clinical trials.

BMJ open·2013
Same author

Self-assembly: Proteins on parade.

Nature chemistry·2012
Same author

Interventions for treatment of neonatal hyperglycemia in very low birth weight infants.

The Cochrane database of systematic reviews·2011
Same author

Interventions for prevention of neonatal hyperglycemia in very low birth weight infants.

The Cochrane database of systematic reviews·2011

Related Experiment Video

Updated: May 3, 2026

High-throughput Protein Expression Generator Using a Microfluidic Platform
09:26

High-throughput Protein Expression Generator Using a Microfluidic Platform

Published on: August 23, 2012

11.1K

Constructing arrays of proteins.

John C Sinclair

    Current Opinion in Chemical Biology
    |January 28, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Researchers are creating ordered protein arrays for structural biology and nanotechnology. Exploiting protein symmetry and novel interface design enables precise protein arrangement and structure determination.

    More Related Videos

    Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
    08:07

    Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

    Published on: August 2, 2015

    7.4K
    The MultiBac Protein Complex Production Platform at the EMBL
    13:51

    The MultiBac Protein Complex Production Platform at the EMBL

    Published on: July 11, 2013

    15.8K

    Related Experiment Videos

    Last Updated: May 3, 2026

    High-throughput Protein Expression Generator Using a Microfluidic Platform
    09:26

    High-throughput Protein Expression Generator Using a Microfluidic Platform

    Published on: August 23, 2012

    11.1K
    Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
    08:07

    Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

    Published on: August 2, 2015

    7.4K
    The MultiBac Protein Complex Production Platform at the EMBL
    13:51

    The MultiBac Protein Complex Production Platform at the EMBL

    Published on: July 11, 2013

    15.8K

    Area of Science:

    • Biophysics
    • Structural Biology
    • Nanotechnology

    Background:

    • Crystalline protein arrays offer dense, oriented, and functional presentation for structural determination.
    • Rational design of supramolecular protein structures is advancing rapidly.
    • Exploiting innate protein symmetry and protein-interface design are key strategies.

    Purpose of the Study:

    • To explore the rational design of crystalline protein arrays.
    • To highlight the benefits of using innate protein symmetry and advanced interface design.
    • To discuss the potential of metal coordination and peptide binding for array formation.

    Main Methods:

    • Leveraging existing protein symmetry to minimize non-native interfaces.
    • Designing symmetric protein-protein interfaces for improved alignment.
    • Utilizing metal coordination and peptide binding for reversible inter-particle associations.

    Main Results:

    • Successful construction of ordered protein arrays is becoming more feasible.
    • Symmetric interfaces facilitate precise protein alignment within arrays.
    • Malleable interactions like metal coordination and peptide binding show promise for array stability and control.

    Conclusions:

    • Advances in protein symmetry and interface design are enhancing the construction of crystalline protein arrays.
    • Metal coordination and peptide binding offer versatile strategies for creating functional protein assemblies.
    • This field holds significant promise for both nanotechnology and structural biology applications.