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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Translation01:31

Translation

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
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Translation01:31

Translation

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
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[Non-coding RNAs and diseases].

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    Non-coding RNAs (ncRNAs) are crucial in biological processes and diseases. This review summarizes the role of various ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), in human disease pathogenesis.

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    Area of Science:

    • Genomics and Molecular Biology
    • RNA Biology

    Context:

    • Large-scale genomic sequencing has revealed numerous non-coding RNAs (ncRNAs).
    • ncRNAs are broadly classified into small ncRNAs (microRNAs, PIWI-interacting RNAs, short interfering RNAs) and long ncRNAs (lncRNAs).
    • These molecules play vital roles in fundamental biological processes.

    Purpose:

    • To summarize current knowledge on the function of ncRNAs in human diseases.
    • To provide an overview of the diverse roles ncRNAs play in health and disease.

    Summary:

    • ncRNAs are implicated in eukaryotic growth, development, cell proliferation, differentiation, and apoptosis.
    • Dysregulation of ncRNAs is associated with the pathogenesis of various human diseases.
    • This review consolidates information on disease-associated ncRNAs.

    Impact:

    • Highlights the significance of ncRNAs in understanding disease mechanisms.
    • Provides a valuable resource for researchers investigating ncRNA-based diagnostics and therapeutics.
    • Emphasizes the expanding role of ncRNAs beyond protein-coding genes in human health.