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A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

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Complement components as potential therapeutic targets for asthma treatment.

Mohammad Afzal Khan¹, Mark R Nicolls², Besiki Surguladze³

¹Department of Applied Biology, College of Sciences, University of Sharjah, Sharjah, United Arab Emirates.

Respiratory Medicine

|January 29, 2014

Summary

Asthma involves airway inflammation. Targeting the complement system, part of the innate immune system, offers a promising new approach for asthma immunotherapy.

Keywords:

Anaphylatoxins Asthma Complement mediated injury

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Area of Science:

Immunology
Respiratory Medicine
Allergy

Background:

Asthma is a prevalent respiratory disorder marked by airway inflammation and hyperresponsiveness.
Current treatments like corticosteroids lack specificity, highlighting the need for novel therapeutic strategies.
The innate immune system, particularly the complement cascade, plays a significant role in asthma pathogenesis.

Purpose of the Study:

To review the role of complement-mediated injury in asthma.
To explore the therapeutic potential of blocking complement mediators in asthma.

Main Methods:

Literature review focusing on complement system activation in asthma.
Analysis of pathophysiological features of asthma linked to complement components.
Evaluation of potential therapeutic strategies targeting complement mediators.

Main Results:

Complement proteins (C3 and C5) are implicated in asthma's inflammatory processes.
Complement activation contributes to inflammatory cell infiltration, mucus production, and airway hyperreactivity.
Blockade of complement mediators presents a potential immunotherapy for asthma.

Conclusions:

Complement-mediated injury is a key factor in asthma inflammation.
Targeting the complement cascade offers a promising avenue for novel asthma therapies.
Further research into complement inhibition could lead to effective asthma treatments.