Related Experiment Video

Updated: May 3, 2026

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting
11:37

Protocol for MicroRNA Transfer into Adult Bone Marrow-derived Hematopoietic Stem Cells to Enable Cell Engineering Combined with Magnetic Targeting

Published on: June 18, 2018

6.2K

Bone marrow cell therapy in cardiovascular disease drives us slowly to a better identification of the active cell

David M Smadja

    Stem Cell Research & Therapy
    |January 29, 2014
    PubMed

    Insights

    Bone marrow mononuclear cells (BM-MNCs) show promise in regenerating tissue after acute myocardial infarction (AMI). These cells can overcome smoking-related damage, suggesting they are more than just endothelial progenitor cells.

    Area of Science:

    • Regenerative Medicine
    • Cardiovascular Research
    • Cell Therapy

    Background:

    • Acute myocardial infarction (AMI) poses significant challenges for cardiac tissue regeneration.
    • Endothelial progenitor cell (EPC) and stem cell therapies are investigated for AMI recovery.
    • Previous research highlighted the role of progenitors in AMI patients and their correlation with therapy efficacy.

    Purpose of the Study:

    • To analyze progenitor cells in the blood and bone marrow of AMI patients.
    • To correlate progenitor levels with the efficacy of bone marrow mononuclear cell (BM-MNC) therapy.
    • To investigate the influence of smoking status on these cellular components and therapy outcomes.

    Main Methods:

    • Analysis of progenitor cells in blood and bone marrow samples from AMI patients.
    • Correlation of progenitor cell levels with BM-MNC therapy outcomes.
    • Assessment of the impact of smoking on endothelial lineage and progenitor cell function.

    Main Results:

    • Bone marrow mononuclear cells (BM-MNCs) demonstrated the ability to counteract smoking-induced alterations in the endothelial lineage.
    • Endothelial progenitor cells (EPCs) were found to be unlikely to be the sole active component in BM-MNC therapy for AMI.
    • A complex cellular composition within BM-MNCs contributes to therapeutic efficacy in AMI.

    Conclusions:

    • BM-MNCs possess regenerative capabilities in AMI that extend beyond the direct action of EPCs.
    • The cellular complexity of BM-MNCs is crucial for understanding their therapeutic potential in acute myocardial infarction.
    • Therapeutic strategies for AMI should consider the multifaceted nature of cell therapy components.

    More Related Videos

    Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy11:51

    Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

    Published on: March 1, 2016

    9.9K
    In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells05:32

    In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

    Published on: February 16, 2024

    1.2K

    Related Concept Videos

    Stem Cell Therapy for Tissue Regeneration01:21

    Stem Cell Therapy for Tissue Regeneration

    Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
    Types of Stem Cells used in Stem Cell Therapy
    The two main cell...
    3.8K
    Bone Marrow Sampling and Transplants01:22

    Bone Marrow Sampling and Transplants

    Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
    The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
    3.0K
    Stem Cell Culture01:17

    Stem Cell Culture

    Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
    4.5K