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Galanin: a potent modulator of excitatory neurotransmission in the human urinary bladder
C A Maggi1, P Santicioli, R Patacchini
1Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
European Journal of Pharmacology
|November 3, 1987
Abstract:
Galanin (GAL) produced a concentration (0.3-100 nM)-related inhibition of the atropine-sensitive component of the contractions induced by field stimulation of detrusor strips from the dome of the human urinary bladder. GAL had an ED50 of 2 nM for the inhibition. The effect of GAL was prevented by atropine (1 microM) and was not seen when the strips were stimulated with a cholinomimetic or KCl. These data suggest a possible neuromodulator role of GAL in the human urinary bladder.