Search research articles

Search research articles

Related Experiment Videos

Membrane currents in cardiac pacemaker tissue.

¹National Institute for Physiological Sciences, Aichi Prefecture, Japan.

|December 1, 1987

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil-Bosentan and Sildenafil-Ambrisentan Combination Therapies for Pulmonary Hypertension.

Clinical and translational science·2016

Same author

Immunological abnormalities in splenic marginal zone cell lymphoma.

American journal of hematology·1997

Same author

[Syphilitic thoracic aortic aneurysm with destruction of vertebral body, producing numbness of lower extremities and paraplegia].

Kyobu geka. The Japanese journal of thoracic surgery·1995

Same author

Cardiac pacemaking in the sinoatrial node.

Physiological reviews·1993

Same author

Stretch-activated anion currents of rabbit cardiac myocytes.

The Journal of physiology·1992

Same author

Background current in sino-atrial node cells of the rabbit heart.

The Journal of physiology·1992

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

This study surveys cardiac pacemaker mechanisms in sinoatrial node cells. Advanced techniques reveal key ionic currents crucial for heart rhythm generation and depolarization.

Area of Science:

Cardiology
Electrophysiology
Cellular Biology

Background:

Cardiac pacemaker function is essential for maintaining heart rhythm.
Understanding sinoatrial node cell mechanisms is key to cardiac electrophysiology.
Traditional methods for studying multicellular cardiac tissue present challenges.

Purpose of the Study:

To provide a concise overview of the cardiac pacemaker mechanism in sinoatrial node cells.
To highlight the advancements in techniques used to study these mechanisms.
To discuss the physiological significance of identified ionic currents.

Main Methods:

Single cell isolation technique.
Patch clamp technique for whole-cell and single-channel analysis.
Voltage clamp methods adapted for cellular preparations.

Related Experiment Videos

Main Results:

Identification of key ionic currents: calcium current (ICa), delayed rectifier potassium current (IK), transient outward current (Ito;IA), and hyperpolarization-activated inward current (Ih or If).
Demonstration that these currents are present in both whole-cell and single-channel analyses.
Confirmation that these techniques overcome limitations of multicellular preparations.

Conclusions:

Single cell isolation and patch clamp techniques have significantly advanced the study of cardiac pacemaker mechanisms.
Specific ionic currents (ICa, IK, Ito;IA, Ih/If) play critical roles in sinoatrial node cell function.
Further understanding of these currents and exchange systems is vital for comprehending pacemaker depolarization.