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Updated: May 3, 2026
On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
Published on: March 17, 2023
Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release
Bárbara Herranz-Blanco1, Laura R Arriaga, Ermei Mäkilä
1Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. helder.santos@helsinki.fi.
Abstract:
A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.
