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[Executive task performance under deep brain stimulation of the subthalamic nucleus in Parkinson's disease revisited: the modulating influence of apathy, depression and mood].

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Related Experiment Video

Updated: May 3, 2026

Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression
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[Deep brain stimulation as possible alternative for therapy resistant depression].

T E Schläpfer1

  • 1Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland, schlaepf@jhmi.edu.

Der Nervenarzt
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Summary

Deep brain stimulation (DBS) is a safe and effective treatment for neurological disorders. This article addresses misconceptions about DBS, particularly for treating resistant depression, highlighting its potential for neuropsychiatric conditions.

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Area of Science:

  • Neuromodulation
  • Neurosurgery
  • Psychiatry

Context:

  • Deep brain stimulation (DBS) is an established therapy for neurological conditions like Parkinson's disease.
  • Significant misunderstandings persist regarding DBS, especially for neuropsychiatric applications.
  • Over 100,000 patients globally have undergone DBS for various disorders.

Purpose:

  • To clarify the methodology and applications of DBS.
  • To address and overcome prevalent prejudices surrounding DBS in neuropsychiatric treatment.
  • To explore the future potential and development of DBS for complex conditions like resistant depression.

Summary:

  • Deep brain stimulation (DBS) involves surgically implanting electrodes in specific brain regions to modulate neural activity.
  • The procedure is clinically validated, with over a decade of use in treating movement disorders.
  • This article examines DBS, using resistant depression as a case study, to demystify its use in neuropsychiatry.

Impact:

  • Potential to reduce patient and clinician apprehension towards DBS for neuropsychiatric disorders.
  • Facilitates broader consideration of DBS as a therapeutic option for treatment-resistant depression.
  • Advances understanding of DBS's role in modulating brain circuits for complex neurological and psychiatric conditions.