Related Experiment Video

Updated: May 3, 2026

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII
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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry CE-ICP-MS for Quantification of Iron Redox Species FeII, FeIII

Published on: May 4, 2020

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Manganese in health and disease

Daiana Silva Avila1, Robson Luiz Puntel, Michael Aschner

  • 1Biochemistry Graduation Program, Universidade Federal do Pampa, Uruguaiana, Rio Grande do Sul, Brazil, avilads1@gmail.com.

Metal Ions in Life Sciences
|January 29, 2014
PubMed

Insights

Manganese (Mn) is vital for human health but toxic in excess, causing neurodegenerative manganism with parkinsonian symptoms. This review explores Mn

Area of Science:

  • Biochemistry
  • Neuroscience
  • Toxicology

Background:

  • Manganese (Mn) is an essential trace element crucial for human development, metabolism, and antioxidant defenses.
  • However, elevated exposure to Mn can induce manganism, a neurodegenerative condition.
  • Manganism is characterized by dopaminergic neuronal loss, leading to parkinsonian-like symptoms.

Purpose of the Study:

  • To review the essential roles of manganese in human health.
  • To elucidate the mechanisms of manganese-induced neurotoxicity.
  • To discuss diseases associated with excessive manganese exposure.

Main Methods:

  • Literature review of scientific articles on manganese.
  • Analysis of studies on manganese metabolism and toxicity.
  • Synthesis of information on manganism and its clinical manifestations.

Main Results:

  • Manganese is indispensable for various physiological processes.
  • Excessive manganese exposure leads to neurodegeneration, mimicking Parkinson's disease.
  • The dual role of manganese highlights its Janus-faced nature in biological systems.

Conclusions:

  • Understanding manganese's essentiality and toxicity is critical for public health.
  • Further research is needed to develop effective treatments for manganese-induced neurotoxicity.
  • This review provides a comprehensive overview of manganese's impact on human health.

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