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Updated: May 3, 2026

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
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Published on: July 29, 2011

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Development of anticancer drugs based on the hallmarks of tumor cells

Natalia Bailón-Moscoso1, Juan Carlos Romero-Benavides, Patricia Ostrosky-Wegman

  • 1Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), Circuito Escolar, Cd. Universitaria, Coyoacán, 04510, México, D.F., México.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|January 29, 2014
PubMed

Insights

This review explores cancer drugs targeting the hallmarks of cancer, focusing on molecular interactions and therapeutic development. Understanding these cancer hallmarks drives innovative treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer is a major public health issue with significant unmet medical needs.
  • Advances in understanding cancer's molecular and biological traits (hallmarks of cancer) have spurred new therapeutic strategies.
  • Current cancer drugs often target specific molecular pathways linked to these hallmarks.

Purpose of the Study:

  • To review existing cancer drugs based on their interaction with the hallmarks of cancer.
  • To discuss the development of novel cancer therapeutics in relation to these hallmarks.
  • To examine the underlying pathways and mechanisms targeted by these drugs.

Main Methods:

  • Literature review of current cancer drugs.
  • Analysis of drug development strategies.
  • Examination of molecular targets and biological pathways related to cancer hallmarks.

Main Results:

  • Identification of key molecular targets associated with cancer hallmarks.
  • Overview of therapeutic approaches exploiting these targets.
  • Discussion of the evolution of cancer drug development.

Conclusions:

  • Targeting cancer hallmarks is central to modern cancer therapy.
  • Continued research into molecular pathways is crucial for developing more effective cancer drugs.
  • A deeper understanding of drug interactions with cancer hallmarks will advance treatment outcomes.

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