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Updated: May 3, 2026

Contrast Enhanced Vessel Imaging using MicroCT
Published on: January 27, 2011
Spectral CT: a technology primer for contrast agent development
Carsten O Schirra1, Bernhard Brendel, Mark A Anastasio
1Philips Research North America - Briarcliff Manor, Clinical Informatics, Interventional, and Translational Solutions, 345 Scarborough Road, Briarcliff Manor, NY, 10510, USA.
Abstract:
Recent developments in spectral CT systems featuring binned photon-counting detector technology have enabled an imaging concept on a pre-clinical level that has been coined K-edge imaging. This exciting concept allows the selective and quantitative imaging of contrast media by exploiting the K-edge discontinuity in the photo-electric component of X-ray absorption. An ideal application for K-edge imaging is CT imaging of target-specific and conventional contrast agents that have been designed to be spectral-CT-visible. Current limitations in detector hardware, however, result in typically high noise levels that hamper the application of K-edge imaging. In order to battle noise and assure sufficient sensitivity, the development of dedicated K-edge contrast media in combination with advanced image processing techniques is imperative. This work attempts a comprehensive overview on how the concert of dedicated contrast media, optimized data acquisition and innovative data processing techniques improve sensitivity of K-edge imaging which will foster clinical translation of the technology.
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