Related Experiment Video
Updated: May 3, 2026
11:15
Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
7.2K
Glioma virus therapies between bench and bedside
Johanna K Kaufmann1, E Antonio Chiocca
1Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.
Neuro-Oncology
|January 29, 2014
Summary
Novel viral therapies show promise for brain cancer (glioma) treatment, but require enhanced targeting and delivery for greater efficacy. Future strategies focus on improving viral vectors and immune responses for better outcomes.
Area of Science:
- Neuro-oncology
- Virology
- Immunotherapy
Background:
- Current glioma treatments remain largely unsatisfactory, necessitating innovative therapeutic strategies.
- Oncolytic viruses and viral vectors represent emerging modalities for brain cancer therapy.
- Clinical trials indicate viral therapies are generally safe for glioma patients, with established maximum tolerated doses.
Purpose of the Study:
- To review the outcomes of completed glioma virus therapy trials and ongoing clinical activities.
- To provide an overview of strategies for enhancing the efficacy of next-generation therapeutic viruses.
- To discuss future approaches crucial for developing successful glioma therapies.
Main Methods:
- Review of completed and ongoing clinical trials in glioma virus therapy.
- Analysis of mechanisms underlying viral cytotoxicity in brain tumors.
- Exploration of strategies to improve viral vector design and delivery methods.
Main Results:
- Viral therapies have demonstrated safety in glioma patients, though therapeutic benefits are currently limited.
- New generations of viral vectors need to target both tumor cells and the microenvironment.
- Enhancing viral spread and directing long-lasting immune responses are key challenges.
Conclusions:
- Further development of advanced viral vectors is essential for improved glioma treatment.
- Optimizing delivery methods and enhancing viral spread within the tumor are critical.
- Future research should focus on novel treatment regimens and combination therapies to overcome limitations.
Related Concept Videos
02:49Cancer Therapies
8.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.5K
01:22Alzheimer's Disease: Treatment
1.3K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.3K
01:27Tumor Immunotherapy
2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
01:29Microorganisms in Medicine and Therapeutics
1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K