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Human T Lymphotropic Virus Type I (HTLV-I) is a Risk Factor for Coronary Artery Disease

Reza Farid Hosseni1, Farahzad Jabbari2, Mahmoud Shabestari3

  • 1Allergy Research Centre.

Iranian Journal of Basic Medical Sciences
|January 29, 2014
PubMed

Insights

Human T-lymphotropic virus type I (HTLV-I) infection is associated with a higher prevalence of coronary artery disease (CAD) in Neyshabour. This finding suggests HTLV-I may be a significant risk factor for heart complications in this endemic region.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Limited research exists on the association between Human T-lymphotropic virus type I (HTLV-I) infection and coronary artery disease (CAD).
  • HTLV-I has been identified in cardiac tissues, particularly in cases of lymphoma/leukemia.
  • Mashhad and Neyshabour, Iran, are recognized endemic areas for HTLV-I.

Purpose of the Study:

  • To investigate the impact of HTLV-I infection on the prevalence of CAD among patients in Neyshabour, Iran.
  • To determine the seroprevalence of HTLV-I in a population with diagnosed coronary artery disease.

Main Methods:

  • A cohort of 7590 patients admitted to Razavi and Imam Reza Hospitals between 2007-2008 was studied.
  • HTLV-I seroprevalence was assessed using Enzyme-Linked Immunosorbent Assay (ELISA) and confirmed by Polymerase Chain Reaction (PCR).
  • Statistical analyses were conducted using SPSS software.

Main Results:

  • Among 564 residents of Neyshabour, the HTLV-I seroprevalence was 13%.
  • Of 294 patients with abnormal angiography (CAD), 14.6% were HTLV-I seropositive.
  • The PCR-confirmed HTLV-I infection rate in patients with CAD was 10.54%, nearly three times higher than the general population's rate (3.4%).

Conclusions:

  • The seroprevalence of HTLV-I is significantly elevated in Neyshabour patients with heart complications compared to the general population.
  • HTLV-I infection is associated with an increased risk of coronary artery disease in this Iranian population.
  • Additional co-factors may contribute to the development of heart complications in Neyshabour, alongside HTLV-I infection.
Abstract

Keywords:
Coronary Artery Disease (CAD)HTLV-IRisk factor

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