Related Experiment Video

Updated: May 3, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.7K

Fecal microbiota transplantation: the state of the art

Stefano Di Bella1, Cecilia Drapeau2, Esther García-Almodóvar3

  • 1National Institute for Infectious Diseases L. Spallanzani , Rome, Italy ;

Infectious Disease Reports
|January 29, 2014
PubMed

Insights

Fecal microbiota transplantation is a promising treatment for difficult Clostridium difficile infections. This approach is safe, effective, and cost-efficient, potentially becoming a standard therapy for challenging CDI cases.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Clostridium difficile infection (CDI) presents increasing incidence, morbidity, and mortality.
  • Existing treatments are often ineffective for recurrent, refractory, or complicated CDI cases.

Purpose of the Study:

  • To review the pathophysiological basis of gut microbiota transplantation.
  • To outline the clinical indications for fecal microbiota transplantation in managing CDI.

Main Methods:

  • Review of existing scientific literature and clinical evidence.
  • Analysis of the efficacy, safety, and cost-effectiveness of fecal microbiota transplantation.

Main Results:

  • Fecal microbiota transplantation has demonstrated proven efficacy and safety.
  • The technique is cost-effective compared to other treatment options.

Conclusions:

  • Fecal microbiota transplantation is a viable and effective option for difficult CDI cases.
  • This therapy is poised for inclusion in future clinical management guidelines for challenging CDI.
Keywords:
Clostridium difficile infectionmicrobiota transplantation

More Related Videos

Murine Fecal Isolation and Microbiota Transplantation07:32

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

5.6K
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

26.7K

Related Concept Videos

What is Monogastric Digestion?01:50

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
56.5K
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
233
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity,...
209
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
61
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.7K