Related Experiment Video
Updated: May 3, 2026
Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40
M Aziz1, M L M Wissing, K V Naver
1Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences, Herlev Hospital, Copenhagen University , Herlev , Denmark .
Objective:
To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.
Design:
Cross-sectional study.
Setting:
Gynecological clinics at three Danish University Hospitals.
Patients:
One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.
Main Outcome Measures:
Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.
Results:
No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.
Conclusion:
YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.
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