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Digital Microfluidics for Automated Proteomic Processing
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Multiplexed extraction and quantitative analysis of pharmaceuticals from DBS samples using digital microfluidics.

Nelson M Lafrenière1, Steve C C Shih, Paul Abu-Rabie

  • 1Department of Chemistry, University of Toronto, 80 St George St., Toronto, ON, M5S 3H6, Canada.

Bioanalysis
|January 30, 2014
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Digital microfluidics streamlines dried blood spot (DBS) analysis for pharmaceuticals. This new method significantly reduces processing time and solvent use, improving efficiency in drug testing.

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Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Pharmaceutical Science

Background:

  • Dried blood spot (DBS) sampling is increasingly utilized in clinical and preclinical pharmaceutical testing.
  • Current DBS sampling and analysis methods are often laborious and time-consuming.
  • Digital microfluidics offers a potential solution for automating and accelerating DBS analysis.

Purpose of the Study:

  • To develop a novel digital microfluidic method for the multiplexed extraction and analysis of pharmaceuticals from DBS samples.
  • To address the limitations of conventional DBS processing.

Main Methods:

  • A digital microfluidic system was employed to handle microliter-sized droplets containing DBS extracts and internal standards.
  • Multiplexed extraction of four DBS samples was performed.
  • Extracts were directly delivered to nanoelectrospray ionization emitters for tandem mass spectrometry (MS/MS) analysis using selected reaction monitoring (SRM).

Main Results:

  • The developed method enables the simultaneous extraction and analysis of multiple DBS samples.
  • The digital microfluidic approach significantly reduces processing time by an order of magnitude compared to conventional methods.
  • Extraction solvent consumption was reduced by approximately three-fold.

Conclusions:

  • The new digital microfluidic method offers a substantial improvement in efficiency for DBS pharmaceutical analysis.
  • The method maintains acceptable analytical performance for a majority of the drugs evaluated.
  • This technique presents a promising advancement for high-throughput pharmaceutical testing using DBS samples.