Related Experiment Videos
Kinins are generated during experimental rhinovirus colds.
R M Naclerio1, D Proud, L M Lichtenstein
1Department of Medicine, Johns Hopkins University, Baltimore, Maryland.
The Journal of Infectious Diseases
|January 1, 1988
Summary
Rhinovirus infections cause kinin generation, increased vascular permeability, and neutrophil infiltration in nasal secretions. Histamine levels remained unchanged, indicating specific inflammatory pathways are involved in common cold symptoms.
Area of Science:
- Immunology
- Respiratory Medicine
- Pathophysiology
Background:
- The common cold is frequently caused by rhinovirus.
- Understanding the underlying pathophysiology of rhinovirus infections is crucial for symptom management.
Purpose of the Study:
- To investigate the pathophysiological mechanisms of rhinovirus-induced common cold symptoms.
- To identify biomarkers associated with rhinovirus infection severity.
Main Methods:
- Volunteers were challenged with rhinovirus or placebo.
- Nasal lavages were collected over five days post-challenge.
- Levels of histamine, kinins, TAME-esterase activity, albumin, and neutrophils were measured.
Main Results:
- Symptomatic individuals showed increased kinins, TAME-esterase activity, albumin, and neutrophils.
- Histamine levels did not significantly change.
- Symptom severity correlated with increased kinins, albumin, TAME-esterase activity, and neutrophils.
Conclusions:
- Symptomatic rhinovirus infections involve kinin generation and increased vascular permeability.
- Neutrophils infiltrate nasal secretions, but basophils and mast cells do not appear to play a significant role.
- These findings elucidate key inflammatory mediators in rhinovirus colds.