Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

41
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
41
Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
Inflammation: Introduction01:28

Inflammation: Introduction

64
Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
64
Inflammation01:38

Inflammation

46.6K
Overview
46.6K
Mitochondria01:37

Mitochondria

13.4K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is Adopting a Microteams Model a Solution to Delivering Continuity of Care in Modern Primary Care?

Journal of primary care & community health·2026
Same author

A randomised controlled crossover study to assess adherence and palatability of a porridge supplement compared to a drink-based supplement in hospitalised older adults at risk of malnutrition.

Journal of nutritional science·2026
Same author

RYR1<sup>+</sup> skeletal muscle-derived extracellular vesicles are exercise responsive and associated with insulin action.

Journal of translational medicine·2026
Same author

Inhibition of Autophagy Reveals ATR Protein Kinase as a Key Mediator of Cisplatin Sensitivity in Osteosarcoma.

Cancer medicine·2026
Same author

Diet Quality Trajectories and Musculoskeletal Health Among the Oldest Old: Findings from the Hertfordshire Cohort Study.

Nutrients·2026
Same author

Single-Cell RNAseq Identifies Heterogeneity in Myoblasts From Older Adults With Differences Related to Muscle Mass and Function.

Journal of cachexia, sarcopenia and muscle·2026

Related Experiment Video

Updated: May 3, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.2K

Understanding how we age: insights into inflammaging.

Daniel Baylis1, David B Bartlett, Harnish P Patel

  • 1Department of Medicine for Older People, University Hospital Southampton, Southampton, UK. db@mrc.soton.ac.uk.

Longevity & Healthspan
|January 30, 2014
PubMed
Summary

Inflammaging, an age-related inflammatory response, involves immune system changes and genetic/environmental factors. It

More Related Videos

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

34.4K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

10.1K

Related Experiment Videos

Last Updated: May 3, 2026

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.2K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

34.4K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

10.1K

Area of Science:

  • Gerontology and immunology research.
  • Focuses on the biological mechanisms of aging.

Background:

  • Inflammaging is chronic, low-grade inflammation associated with aging.
  • It stems from immune system remodeling and contributes to age-related diseases.
  • Genetic, environmental, and lifestyle factors influence individual susceptibility.

Purpose of the Study:

  • To explore the concept of inflammaging and its implications.
  • To discuss the role of anti-inflammaging and hormonal regulation.
  • To highlight the link between inflammaging and adverse aging outcomes.

Main Methods:

  • Review of existing literature on inflammaging.
  • Analysis of immune system changes with age.
  • Examination of genetic and environmental influences.

Main Results:

  • Inflammaging involves chronic cytokine production due to immune system remodeling.
  • Factors like genetic polymorphisms, autophagy decline, and adiposity contribute to inflammaging.
  • Anti-inflammaging (cortisol upregulation) and declining dehydroepiandrosterone (DHEA) impact aging.
  • Both phenomena are linked to morbidity, functional decline, and mortality.

Conclusions:

  • Inflammaging and anti-inflammaging are key processes in aging.
  • Understanding these processes is crucial for developing interventions.
  • Further research can lead to targeted screening and treatments for age-related conditions.