Related Experiment Video
Updated: May 3, 2026

Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of M. abscessus Treatments
Published on: October 25, 2024
Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4-diones
Singanan Ponnuchamy1, Selvaraj Kanchithalaivan2, Raju Ranjith Kumar2
1Orchid Chemicals & Pharmaceuticals Ltd, R&D Center, Chennai 600119, India.
Abstract:
A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM. Compound 1m exhibited maximum potency being 5.87 fold more active at EC50 and 6.26 fold more active at EC90 than the standard drug pyrimethamine.
Related Concept Videos
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Antimicrobial Effectiveness
Antihypertensive Drugs: Thiazide-Class Diuretics
Inhibitors of Bacterial DNA Synthesis
Antifungal Agents
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
