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Updated: May 3, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Bedside consultation by a multidisciplinary antibiotics team: an Antibiotic Stewardship Programme at UMCG]
Jerome R Lo-Ten-Foe1, Bhanu Sinha, Kasper R Wilting
1UMCG, Groningen.
Insights
Dutch hospitals are implementing antibiotic stewardship programs (ASP) to combat rising antibiotic resistance. A pilot project at University Medical Centre Groningen (UMCG) demonstrated a 75% intervention rate using a day 2 bundle, proving successful for wider implementation.
Area of Science:
- Infectious Diseases
- Clinical Pharmacy
- Public Health Policy
Background:
- Rising antibiotic use and resistance pose a significant global health threat.
- The Dutch Working Party on Antibiotic Policy (SWAB) advocated for Antibiotic Stewardship Programmes (ASP) to address this challenge.
- Multidisciplinary antibiotics teams (A-teams) are central to ASP implementation.
Purpose of the Study:
- To evaluate the effectiveness of an ASP pilot project at the University Medical Centre Groningen (UMCG).
- To assess the impact of a day 2 bundle for bedside consultation in a trauma surgery ward.
- To determine the feasibility and success of ASP implementation in a clinical setting.
Main Methods:
- Implementation of an ASP at the UMCG trauma surgery ward in 2012.
- Focus on bedside consultations guided by a "day 2 bundle" protocol.
- Data collection on intervention percentages during the pilot phase.
Main Results:
- The ASP implementation achieved a 75% intervention percentage.
- The pilot project on the trauma surgery ward was deemed successful.
- Positive outcomes indicate potential for broader application within the hospital.
Conclusions:
- ASP implementation, particularly using a day 2 bundle, is effective in managing antibiotic use.
- The UMCG pilot project demonstrates the success of ASP in a clinical setting.
- The program's success warrants expansion to other hospital wards.
Abstract:
In 2012, the Dutch Working Party on Antibiotic Policy (SWAB) published a vision document to counteract the rise in antibiotic use and resistance. An Antibiotic Stewardship Programme (ASP) will be implemented by a multidisciplinary antibiotics team (A-team). In 2012 University Medical Centre Groningen (UMCG) in the Netherlands started an Antibiotic Stewardship Programme (ASP) pilot project at the trauma surgery ward. The focus is on providing bedside consultation for patients based on the day 2 bundle. Implementation of the ASP on the basis of a day 2 bundle resulted in an intervention percentage of 75%. The pilot project was a success and will be extended to other wards.
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