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Hepatitis

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.

Viral Hepatitis I: Introduction

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Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...

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Related Experiment Video

Updated: May 3, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E presenting with thrombocytopaenia.

Irfan Masood¹, Ali Rafiq², Zain Majid³

¹Medical Doctor/General Physician, Department of Medicine, Dow Medical College, Civil Hospital Karachi, Pakistan.

Tropical Doctor

|January 30, 2014

Summary

This summary is machine-generated.

Hepatitis E viral infection can cause low platelet counts (thrombocytopenia) through an immune response. This association should be considered in patients with acute liver failure and thrombocytopenia.

Keywords:

Hepatitis E immune-mediated thrombocytopaenia young male

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Area of Science:

Hepatology
Infectious Diseases
Hematology

Background:

Acute viral hepatitis is a significant global health concern.
Hepatitis E virus (HEV) infection is a common cause of acute liver failure, particularly in developing countries.
Thrombocytopenia (TCP) is a condition characterized by abnormally low levels of platelets.

Observation:

A 25-year-old male presented with symptoms of acute viral hepatitis.
Serological tests confirmed Hepatitis E viral (HEV) infection.
The patient also exhibited thrombocytopenia (TCP) concurrently with HEV infection.

Findings:

The patient's thrombocytopenia resolved following the resolution of jaundice.
Other common causes of thrombocytopenia were ruled out.
An immune-mediated mechanism secondary to HEV infection was proposed as the cause of the patient's low platelet count.

Implications:

HEV infection should be considered in the differential diagnosis of acute liver failure with thrombocytopenia.
This association may occur irrespective of patient age, gender, or geographical location.
Further research into the immune-mediated mechanisms linking HEV and thrombocytopenia is warranted.