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A fully intraocular high-density self-calibrating epiretinal prosthesis.

Manuel Monge, Mayank Raj, Meisam Honarvar Nazari

    IEEE Transactions on Biomedical Circuits and Systems
    |January 30, 2014
    PubMed
    Summary

    This study introduces a self-calibrating epiretinal prosthesis for vision restoration. The 512-channel implantable device features advanced digital calibration and efficient data telemetry for improved performance.

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    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Electrical Engineering

    Background:

    • Epiretinal prostheses aim to restore vision for individuals with retinal degenerative diseases.
    • Previous devices faced challenges with calibration, power, and data transmission.
    • Fully intraocular systems are desirable for reduced invasiveness.

    Purpose of the Study:

    • To present a fully intraocular, self-calibrating epiretinal prosthesis with high channel count.
    • To detail the novel digital calibration technique and dual-band telemetry system.
    • To evaluate the performance and characteristics of the implantable device.

    Main Methods:

    • Design and fabrication of a 512-channel epiretinal prosthesis using 65 nm CMOS technology.
    • Implementation of a novel digital self-calibration technique for biphasic current matching.
    • Development of dual-band telemetry for power and data, including an on-chip rectifier and clock recovery.
    • Integration with MEMS origami coils and parylene substrate for a fully intraocular implant.

    Main Results:

    • The prosthesis features 512 independent channels with arbitrary waveform generation.
    • An efficient on-chip rectifier achieves >80% efficiency, and data telemetry supports up to 20 Mb/s via PSK modulation.
    • In vitro testing demonstrated a low current mismatch (μ = 1.12 μA, σ = 0.53 μA) across multiple channels and chips.
    • The system occupies a compact area of 4.5 × 3.1 mm² with a pixel size of 0.0169 mm².

    Conclusions:

    • The developed fully intraocular epiretinal prosthesis offers a significant advancement in implantable visual prosthetics.
    • The novel self-calibration and telemetry systems enable high performance and reduced component count.
    • This technology holds promise for improving vision restoration in patients with blindness due to retinal diseases.