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Chinese herbal medicine for functional constipation: a randomised controlled trial.

Z X Bian1, C W Cheng, L Z Zhu

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Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi
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Ma Zi Ren Wan (MZRW), a Chinese herbal medicine, significantly improved symptoms of functional constipation compared to placebo. This herbal treatment offers a safe and effective option for managing constipation.

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Integrative Medicine

Background:

  • Functional constipation is a prevalent gastrointestinal disorder.
  • Current treatments may have limitations or side effects.
  • Chinese herbal medicine offers potential therapeutic avenues.

Purpose of the Study:

  • To evaluate the efficacy and safety of Ma Zi Ren Wan (MZRW) for functional constipation.
  • To compare MZRW treatment against a placebo in a randomized controlled trial.

Main Methods:

  • An 18-week prospective, randomized, double-blind, placebo-controlled study.
  • 120 subjects with functional constipation (Rome III criteria) were enrolled.
  • Participants received either MZRW (7.5 g twice daily) or a placebo.

Main Results:

  • The MZRW group showed significantly higher responder rates (43.3% vs. 8.3% during treatment; 30.0% vs. 15.0% follow-up).
  • MZRW improved complete spontaneous bowel movements and reduced constipation severity, straining, and need for rescue therapy.
  • No serious adverse effects were reported in the MZRW group.

Conclusions:

  • Ma Zi Ren Wan is an effective and safe treatment for functional constipation.
  • MZRW demonstrates superiority over placebo in improving key constipation parameters.
  • This study provides a strong foundation for future research on MZRW for constipation.