Related Experiment Video
Updated: May 3, 2026
Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies
Published on: February 2, 2024
CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary
Helena Mocelin1, Gilberto Bueno2, Klaus Irion3
1Santa Casa Sisters of Mercy Hospital Complex in Porto Alegre, Porto Alegre, Brazil.
Objective:
To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB).
Methods:
CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of -950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters.
Results:
The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = -0.58; -0.67), and FEV1/FVC (r = -0.53; r = -0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = -0.40; r = -0.61), 6MWT_SO2 (r = -0.24; r = -0.55), FVC (r = -0.44; r = -0.80), FEV1 (r = -0.65; r = -0.71), and FEV1/FVC (r = -0.41; r = -0.52).
Conclusions:
Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.
Related Concept Videos
01:25Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:15Respiratory Volumes
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
01:26COPD: Management Using Bronchodilators and Corticosteroids
01:29Assessment of Ventilation II: Respiratory Depth and Rhythm
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
01:19Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...