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Updated: May 3, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
Published on: March 19, 2019
Candida famata-induced fulminating cholecystitis
Paulo Sergio Ramos de Araujo1, Zulma Medeiros2, Fabio Lopes de Melo2
1Serviço de Doenças Infecciosas, Hospital das Clínicas, Universidade Federal de Pernambuco, RecifePE.
Abstract:
Lithiasic cholecystitis is classically associated with the presence of enterobacteria, such as Escherichia coli, Enterococcus, Klebsiella, and Enterobacter, in the gallbladder. Cholecystitis associated with fungal infections is a rare event related to underlying conditions such as diabetes mellitus, steroid use, and broad-spectrum antibiotic use for prolonged periods, as well as pancreatitis and surgery of the digestive tract. Here, we present the first reported case of a gallbladder infection caused by Candida famata.
Insights
Gallbladder infections are usually bacterial. This study reports the first case of cholecystitis caused by Candida famata, a rare fungal pathogen, highlighting a unique clinical presentation.
Area of Science:
- Gastroenterology
- Mycology
- Infectious Diseases
Background:
- Gallbladder infections (cholecystitis) are typically linked to bacterial pathogens like Escherichia coli.
- Fungal cholecystitis is uncommon, often occurring in immunocompromised patients or those with specific risk factors.
Observation:
- This case details a gallbladder infection specifically caused by Candida famata.
- Candida famata is a yeast not commonly associated with gallbladder infections.
Findings:
- The study presents the first documented instance of Candida famata causing lithiasic cholecystitis.
- This finding expands the known spectrum of fungal pathogens implicated in gallbladder disease.
Implications:
- This case underscores the importance of considering fungal etiologies in refractory or atypical cholecystitis cases.
- It may prompt further investigation into the role of Candida species in gallbladder infections.
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