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Classification of Leukocytes

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...

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Case for diagnosis. Granular cell tumor.

Thaiane Lima Lage¹, Mario Fernando Ribeiro de Miranda², Maraya de Jesus Semblano Bittencourt³

¹Dermatology Service, Pará Federal University, BelémPA, Brazil, MD, Dermatology resident at the Dermatology Service at Pará Federal University (UFPA)- Belém (PA), Brazil.

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|January 30, 2014

Summary

A rare granular cell tumor, a benign neoplasm of neural origin, was found in a 27-year-old woman. Immunohistochemistry confirmed its neural origin, supporting current research.

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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

Area of Science:

Oncology
Pathology
Dermatology

Background:

Granular cell tumor (GCT) is a rare benign neoplasm.
Its precise cellular origin remains a subject of debate among researchers.
GCTs are most commonly found in the head and neck region.

Observation:

A case study of a 27-year-old female patient with a brown-red nodule on her right arm.
Pathological examination revealed polygonal cells with eosinophilic granular cytoplasm.
Immunohistochemistry testing showed positivity for S100 protein and CD68.

Findings:

The immunohistochemical profile (S100 protein and CD68 positivity) strongly suggests a neural origin for the granular cell tumor.
This finding aligns with the classification of GCT as a neoplasm of neural origin.

Implications:

This case contributes to the understanding of granular cell tumor origins.
Highlights the importance of immunohistochemistry in diagnosing rare tumors.
Further research into GCT pathogenesis may lead to improved diagnostic and therapeutic strategies.