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Updated: May 3, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Do you know this syndrome? POEMS syndrome
Guida Santos1, Sara Lestre2, Alexandre João2
1Dermatology and Venereology Department, Santo António dos Capuchos Hospital, Centro Hospitalar de Lisboa Central, Lisbon, Portugal, MD - Intern in Dermatology and Venereology at the Dermatology and Venereology Department, Santo António dos Capuchos Hospital - Centro Hospitalar de Lisboa Central, E.P.E - Lisbon, Portugal.
Abstract:
POEMS syndrome is a unique clinical entity, the diagnosis of which is made when polyneuropathy and monoclonal gammopathy occur together, associated with other changes such as organomegaly, endocrinopathy, skin changes and papilledema. Cutaneous manifestations are heterogeneous, with diffuse cutaneous hyperpigmentation, hemangiomas and hypertrichosis occurring more frequently. We report the case of a 65- year-old female patient with this syndrome, diagnosed after 15 years of disabling peripheral neuropathy.
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