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Related Concept Videos

Chromatin Packaging01:32

Chromatin Packaging

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Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
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Chromatin Packaging02:21

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Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
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Duplication of Chromatin Structure02:05

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The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
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The Cell Cycle Control System01:28

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
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The Cell Cycle Control System02:11

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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On form and function: does chromatin packing regulate the cell cycle?

David C Corney1, Hilary A Coller

  • 1Molecular, Cell and Developmental Biology, University of California, Los Angeles, California; and Department of Biological Chemistry, David Geffen School of Medicine, Los Angeles, California.

Physiological Genomics
|January 30, 2014
PubMed
Summary
This summary is machine-generated.

Cellular epigenetics influences cell cycle decisions, impacting tissue formation and disease. Understanding this link is key to regulating cell proliferation and quiescence for health.

Keywords:
epigeneticshistone modificationsquiescence

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Area of Science:

  • Systems biology
  • Cellular biology
  • Epigenetics

Background:

  • Cells decide whether to proliferate or reversibly exit the cell cycle.
  • This decision is crucial for tissue development and multicellular processes like healing and immune response.
  • Dysregulation of cell cycle exit can lead to tumor formation.

Purpose of the Study:

  • To explore the intricate relationship between epigenetics and cell cycle regulation.
  • To understand how epigenetic modifications influence a cell's commitment to dividing or non-dividing states.

Main Methods:

  • This perspective piece focuses on existing research.
  • Analysis of studies investigating epigenetic mechanisms and cell cycle control.

Main Results:

  • Epigenetics plays a significant role in determining cell state transitions.
  • Proper epigenetic regulation is essential for controlled cell proliferation and quiescence.

Conclusions:

  • The interplay between epigenetics and the cell cycle is fundamental for normal tissue formation and function.
  • Further research into this relationship can inform strategies for treating diseases associated with cell cycle dysregulation, such as cancer.