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Antiangiogenesis therapy for breast cancer: an update and perspectives from clinical trials

Elham Fakhrejahani1, Masakazu Toi

  • 1*Department of Breast Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan. toi@kuhp.kyoto-u.ac.jp.

Japanese Journal of Clinical Oncology
|January 30, 2014
PubMed

Insights

Antiangiogenic therapies targeting new blood vessel growth show limited clinical impact in breast cancer. This review examines antiangiogenic treatments, their efficacy, safety, and predictive markers for better patient outcomes.

Area of Science:

  • Oncology
  • Vascular Biology
  • Cancer Therapeutics

Background:

  • Angiogenesis, the formation of new blood vessels, is critical for breast cancer progression and metastasis.
  • Breast cancer exhibits heterogeneity, with diverse angiogenic pathways contributing to tumor growth.
  • Antiangiogenic therapies, including anti-vascular endothelial growth factor antibodies, have been investigated for decades.

Purpose of the Study:

  • To review clinical trial data on antiangiogenic therapies for breast cancer.
  • To discuss the safety and efficacy of common antiangiogenic treatments.
  • To explore biological predictive markers for antiangiogenic therapy response.

Main Methods:

  • Systematic review of clinical trial data.
  • Analysis of safety and efficacy of antiangiogenic agents.
  • Evaluation of predictive biomarkers in breast cancer.

Main Results:

  • Antiangiogenic therapy alone or with chemotherapy has shown limited clinical benefit to date.
  • Vascular endothelial growth factor (VEGF) inhibitors are the most studied antiangiogenic agents.
  • Identifying predictive markers is crucial for optimizing treatment strategies.

Conclusions:

  • Despite extensive research, the clinical impact of antiangiogenic therapies in breast cancer remains modest.
  • Further research into predictive markers is essential for personalized antiangiogenic treatment.
  • Optimizing antiangiogenic strategies may improve outcomes in breast cancer patients.
Keywords:
antiangiogenic therapybreast cancerclinical trialpredictive biomarker

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