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Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src
D K Luttrell1, L M Luttrell, S J Parsons
1Department of Microbiology, School of Medicine, University of Virginia, Charlottesville 22908.
Molecular and Cellular Biology
|January 1, 1988
Abstract:
C3H10T1/2 murine fibroblasts overexpressing chicken pp60c-src showed a two- to fivefold enhanced incorporation of [3H]thymidine into DNA in response to epidermal growth factor (EGF) relative to that of the parent line. No difference in growth characteristics, number and affinity of EGF receptors, or hormone potency was attributable to c-src overexpression. These results suggest that pp60c-src may interact with the mitogenic signal transduction pathway of EGF in some event distal to hormone binding.