Related Experiment Video
Updated: May 3, 2026

Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
Low-dose bevacizumab is effective in radiation-induced necrosis
Matheus Alessandretti1, Antonio C Buzaid1, Raphael Brandão1
1Oncology Department, Hospital São José, São Paulo, Brazil.
Background:
Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited.
Methods:
The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported.
Results:
Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective.
Conclusions:
Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.
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