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Src as the link between inflammation and cancer

Sandy T Liu1, Hung Pham2, Stephen J Pandol3

  • 1Department of Medicine, Cedars-Sinai Medical Center Los Angeles, CA, USA ; Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles CA, USA.

Frontiers in Physiology
|January 30, 2014
PubMed

Insights

Chronic inflammation and cancer share molecular links, particularly through Src kinase pathways. This study reveals how Src kinase mediates communication between immune and cancer cells, driving cancer progression.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • A causal link between chronic inflammation and cancer is established.
  • The precise molecular mechanisms connecting inflammation and cancer are not fully understood.
  • Previously, distinct molecular pathways were thought to govern cancer cell development and immune cell infiltration.

Purpose of the Study:

  • To investigate the crosstalk between Src kinase pathways in immune and cancer cells.
  • To elucidate the role of Src family kinases in mediating the link between inflammation and cancer progression.

Main Methods:

  • Evaluation of cross-talk between Src kinase pathways.
  • Analysis of Src activation in cancer and inflammatory cells within the tumor microenvironment.
  • Review of recent evidence on kinase utilization by tumor and immune cells.

Main Results:

  • Both tumor cells and tumor-infiltrating immune cells utilize common kinases, primarily Src family kinases.
  • Src activation in both cell types is driven by pro-inflammatory cytokines in the tumor microenvironment.
  • Src kinase pathways exhibit significant crosstalk between immune and cancer cells.

Conclusions:

  • Src kinase acts as a critical mechanistic link between inflammation and cancer.
  • Src mediates a cycle between immune and tissue cells, promoting cancer development and progression.
  • Targeting Src pathways may offer therapeutic strategies for inflammation-driven cancers.
Keywords:
Srccancerchronic pancreatitiscytokinesinflammationpancreatic cancer

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