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Chronic Inflammation: Introduction01:12

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
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Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Src as the link between inflammation and cancer.

Sandy T Liu1, Hung Pham2, Stephen J Pandol3

  • 1Department of Medicine, Cedars-Sinai Medical Center Los Angeles, CA, USA ; Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles CA, USA.

Frontiers in Physiology
|January 30, 2014
PubMed
Summary

Chronic inflammation and cancer share molecular links, particularly through Src kinase pathways. This study reveals how Src kinase mediates communication between immune and cancer cells, driving cancer progression.

Keywords:
Srccancerchronic pancreatitiscytokinesinflammationpancreatic cancer

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Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • A causal link between chronic inflammation and cancer is established.
  • The precise molecular mechanisms connecting inflammation and cancer are not fully understood.
  • Previously, distinct molecular pathways were thought to govern cancer cell development and immune cell infiltration.

Purpose of the Study:

  • To investigate the crosstalk between Src kinase pathways in immune and cancer cells.
  • To elucidate the role of Src family kinases in mediating the link between inflammation and cancer progression.

Main Methods:

  • Evaluation of cross-talk between Src kinase pathways.
  • Analysis of Src activation in cancer and inflammatory cells within the tumor microenvironment.
  • Review of recent evidence on kinase utilization by tumor and immune cells.

Main Results:

  • Both tumor cells and tumor-infiltrating immune cells utilize common kinases, primarily Src family kinases.
  • Src activation in both cell types is driven by pro-inflammatory cytokines in the tumor microenvironment.
  • Src kinase pathways exhibit significant crosstalk between immune and cancer cells.

Conclusions:

  • Src kinase acts as a critical mechanistic link between inflammation and cancer.
  • Src mediates a cycle between immune and tissue cells, promoting cancer development and progression.
  • Targeting Src pathways may offer therapeutic strategies for inflammation-driven cancers.