Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Smooth Muscle Contraction01:25

Smooth Muscle Contraction

8.7K
Smooth muscle contraction is a complex process vital for various bodily functions, from maintaining blood vessel tension to facilitating the movement of food through the digestive tract. Unlike striated muscles, smooth muscle contraction begins more slowly and lasts longer.
The onset of contraction is triggered by an increase in calcium ions within the sarcoplasm, similar to the process in striated muscle. However, smooth muscles have a relatively smaller reservoir of the sarcoplasmic...
8.7K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Functions of Smooth Muscles01:23

Functions of Smooth Muscles

4.1K
Smooth muscles are an important type of muscle tissue that plays a vital role in the involuntary movements of internal organs. For example, they help regulate the movement of food through the gut and the flow of blood through the circulatory system.
Function of visceral smooth muscles
Visceral smooth muscle is found in the walls of all hollow organs, except the heart, and is a key player in the involuntary movements that drive the functioning of these internal organs. This tissue is arranged in...
4.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

4.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
4.7K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

3.8K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
3.8K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

2.8K
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural and mutational insights define ERMA as the ER Mg<sup>2+</sup> ATPase and reservoir gatekeeper.

Science advances·2026
Same author

Physics-Informed Artificial Intelligence Design of Picomolar Nanobodies Enables Deep Tumor Penetration and High-Contrast Imaging.

Research (Washington, D.C.)·2026
Same author

Leaf-Stomata-Inspired 3D Suspended Ultrasensitive E-Skin for Dual-Modal Tactile and Nociceptive Sensing in Robotics.

Nano letters·2026
Same author

A fully human antibody A140 neutralizes abrin toxin via lysosomal intracellular mechanisms, confers potent protection in vitro and in vivo, and reverses transcriptomic dysregulation with a Favorable safety profile.

Toxicology and applied pharmacology·2026
Same author

Evolutionary Digital Twin for Oil and Gas Pipelines: A Cognitive Multi-Agent Framework with Continuous Feedback Learning.

Sensors (Basel, Switzerland)·2026
Same author

The application effect of the 5E-microteaching integration model in the standardized training of general practitioners.

Frontiers in medicine·2026

Related Experiment Video

Updated: May 3, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

7.8K

Mechanisms simultaneously regulate smooth muscle proliferation and differentiation.

Ning Shi1, Shi-You Chen1

  • 1Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA.

Journal of Biomedical Research
|January 30, 2014
PubMed
Summary
This summary is machine-generated.

Cell division cycle 7 promotes vascular smooth muscle cell (VSMC) differentiation and proliferation. Krüppel-like factor 4 represses these processes, offering insights into cardiovascular disease mechanisms.

Keywords:
Krüppel-like factor 4cell division cycle 7differentiationproliferationvascular smooth muscle

More Related Videos

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
14:47

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

9.6K
Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

7.7K

Related Experiment Videos

Last Updated: May 3, 2026

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

7.8K
Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry
14:47

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

9.6K
Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

7.7K

Area of Science:

  • Vascular biology
  • Cell cycle regulation
  • Cardiovascular disease pathogenesis

Background:

  • Vascular smooth muscle cell (VSMC) differentiation and proliferation are critical for vascular development.
  • Phenotypic switching of VSMCs underlies major cardiovascular diseases like atherosclerosis and hypertension.
  • Understanding VSMC differentiation mechanisms offers insights into disease pathology.

Purpose of the Study:

  • To investigate the molecular mechanisms regulating VSMC differentiation and proliferation concurrently.
  • To highlight the novel role of cell division cycle 7 (CDC7) in VSMC processes.
  • To discuss the repressive role of Krüppel-like factor 4 (KLF4) in VSMC differentiation and proliferation.

Main Methods:

  • Review of recent studies on VSMC differentiation and proliferation.
  • Analysis of the role of cell division cycle 7 in TGF-β-induced VSMC differentiation.
  • Examination of Krüppel-like factor 4's function in suppressing VSMC processes.

Main Results:

  • Cell division cycle 7 promotes both VSMC differentiation and proliferation via distinct mechanisms.
  • Krüppel-like factor 4 acts as a repressor for both VSMC differentiation and proliferation.
  • CDC7's role in TGF-β-induced VSMC changes is highlighted.

Conclusions:

  • CDC7 is a key regulator promoting both VSMC differentiation and proliferation.
  • KLF4 suppresses VSMC differentiation and proliferation.
  • These findings provide fundamental insights into cardiovascular disease development and potential therapeutic targets.