Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Families02:47

Protein Families

13.3K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
13.3K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

13.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of host gene transcripts by machine learning and their application to predict outcome in Ebola virus disease.

The Journal of infectious diseases·2026
Same author

NVX-CoV2372, monovalent mRNA and bivalent mRNA vaccines elicit broadly cross-reactive antibodies against emerging SARS-CoV-2 variants.

Human vaccines & immunotherapeutics·2026
Same author

Optimizing mouse models for mRNA vaccines: addressing dose translation challenges.

Scientific reports·2026
Same author

Human indels as predictors of antibody responses to COVID-19 vaccines.

iScience·2025
Same author

From structure to immunity: how skin shapes age-related vulnerability to Chikungunya virus infections.

Trends in microbiology·2025
Same author

Mosquito salivary sialokinin reduces monocyte activation and chikungunya virus-induced inflammation via neurokinin receptors.

Nature communications·2025

Related Experiment Video

Updated: May 3, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

4.8K

Clustering HLA class I superfamilies using structural interaction patterns.

Sumitro Harjanto1, Lisa F P Ng2, Joo Chuan Tong3

  • 1Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.

Plos One
|January 30, 2014
PubMed
Summary
This summary is machine-generated.

Human leukocyte antigen (HLA) class I molecules

More Related Videos

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

15.2K
Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

21.1K

Related Experiment Videos

Last Updated: May 3, 2026

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
11:17

Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin

Published on: March 10, 2021

4.8K
Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

15.2K
Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers
15:42

Visualizing Antigen Specific CD4+ T Cells using MHC Class II Tetramers

Published on: March 6, 2009

21.1K

Area of Science:

  • Immunology
  • Structural Biology
  • Bioinformatics

Background:

  • Human leukocyte antigen (HLA) class I molecules present intracellular peptides to CD8(+) T cells, crucial for adaptive immunity.
  • Understanding HLA class I specificity is key for vaccine development and immunotherapy.

Purpose of the Study:

  • To analyze the structural interactions between HLA class I molecules and peptides.
  • To develop a novel classification system for HLA class I superfamilies based on structural binding patterns.

Main Methods:

  • Analysis of 16,393 nonameric peptides binding to 58 HLA-A and -B alleles.
  • Characterization of intermolecular bonding patterns between HLA class I molecules and bound peptides.
  • Development of a classification schema based on identified HLA-peptide structural fingerprints.

Main Results:

  • HLA-peptide intermolecular bonding patterns exhibit allele-specific variations.
  • These variations allow for grouping HLA alleles into superfamilies based on structural interactions.
  • A high-resolution classification schema for HLA class I superfamilies was successfully developed.

Conclusions:

  • Structural interaction patterns provide a novel method for defining HLA class I superfamilies.
  • This approach offers an alternative to traditional methods relying on peptide binding motifs or receptor data.
  • The classification can aid in identifying suitable antigens for broad-based subunit vaccine design.