Dietary antioxidents and oxidative stress in predialysis chronic kidney disease patients

Area of Science:

• Nutritional Science
• Nephrology
• Biochemistry

Background:

• Dietary antioxidants play a vital role in preventing human diseases.
• Oxidative stress is a significant risk factor for cardiovascular disease, particularly prevalent in chronic kidney disease (CKD) patients.
• CKD patients exhibit higher levels of oxidative stress compared to healthy individuals.

Purpose of the Study:

• To review the role of dietary antioxidants in chronic kidney disease (CKD).
• To highlight the connection between oxidative stress and nutritional status in CKD patients.
• To emphasize the importance of assessing dietary antioxidants in CKD management.

Main Methods:

• Comprehensive literature search conducted across multiple databases including DOAJ, Google Scholar, PubMed, LISTA, and Web of Science.
• Review of existing research on oxidative stress and dietary factors in CKD.
• Synthesis of findings related to antioxidant intake and oxidative stress markers.

Main Results:

• Oxidative stress results from an imbalance between reactive oxygen species production and antioxidant defenses.
• Insufficient dietary intake of antioxidants is a key factor contributing to oxidative stress.
• Malnourished CKD patients demonstrate elevated levels of oxidative stress compared to well-nourished individuals.

Conclusions:

• Assessing dietary antioxidants is critical for pre-dialysis CKD patients.
• Focusing on dietary antioxidants can help mitigate enhanced oxidative stress in CKD.
• Integrating antioxidant assessment into nutritional strategies is essential for managing CKD patients.