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Related Experiment Video

Updated: May 3, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

Diabetic nephropathy and antioxidants.

¹Department of Anatomy, Lorestan University of Medical Sciences, Faculty of Medicine, Khoram Abad, Iran.

Journal of Nephropathology

|January 30, 2014

Summary

Oxidative stress contributes to diabetic nephropathy (DN). While antioxidants show promise in rodents, their effectiveness in humans is debated, suggesting a need for novel therapeutic strategies like multi-property antioxidants.

Area of Science:

Nephrology
Oxidative Stress Research
Pharmacology

Background:

Oxidative stress is a key factor in the development of diabetic nephropathy (DN).
Antioxidant therapies have shown success in animal models but yield conflicting results in human DN treatment.
Current treatments for DN, including renin-angiotensin system (RAS) blockers, are insufficient, necessitating additional therapeutic agents.

Purpose of the Study:

To review the role of antioxidants in diabetic nephropathy (DN) pathogenesis.
To identify potential therapeutic strategies for human DN based on existing research.
To explore the potential of multi-property antioxidants for improving DN treatment.

Main Methods:

Comprehensive literature search of major scientific databases including DOAJ, Google Scholar, PubMed, LISTA, and Web of Science.

Keywords:

Antioxidants Diabetic nephropathy Oxidative stress

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Review of experimental and human research on oxidative stress and diabetic nephropathy.

Analysis of the characteristics of effective antioxidant therapies for potential application in human DN.

Main Results:

Antioxidants are considered promising candidates for combating DN, given its pathogenesis and research evidence.
Novel multi-property antioxidants with high antioxidant capacity, long half-life, mitochondrial permeability, enhanced enzyme activity, and anti-inflammatory effects may improve human DN.
Rosmarinic acid, a multi-property antioxidant, shows potential based on studies in diabetic rats.

Conclusions:

Rosmarinic acid, a multi-property antioxidant, may offer therapeutic benefits for patients with diabetic nephropathy (DN).
Further clinical trials are required to validate the efficacy of rosmarinic acid and similar agents in human DN treatment.